Palladium-Catalyzed Regioselective Allylic Oxidation of Amorphadiene, a Precursor of Artemisinin
نویسندگان
چکیده
A regioselective Pd-catalyzed allylic oxidation of amorphadiene, a key precursor to the antimalarial drug artemisinin, is described. Amorphadiene can be obtained in high yields by fermentation, but it currently treated as waste industrial semisynthetic artemisinin process. The catalytic step described here substitute for P450 enzymes involved biosynthesis and opens up new opportunities supplement critical current route increase potential fermentation
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ژورنال
عنوان ژورنال: Journal of Organic Chemistry
سال: 2021
ISSN: ['1520-6904', '0022-3263']
DOI: https://doi.org/10.1021/acs.joc.1c00653